2024 Klf4 atherosclerosis

Klf4 atherosclerosis

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August undefined, 2024

WebJul 17, 2024 · Taken together, our results suggest that most SMC phenotypes in advanced atherosclerotic lesions are conserved between humans and mice, and, taken with previous knowledge that SMC Klf4 is atheropromoting in mice and contains a human GWAS CAD … WebAug 1, 2024 · However, since the clinical consequences of atherosclerosis typically occur well after our reproductive years, we sought to identify beneficial KLF4-dependent SMC functions that were likely to be evolutionarily conserved. We tested the hypothesis that …

Fate and State of Vascular Smooth Muscle Cells in …

WebAtherosclerosis, the leading cause of death, is a vascular disease of... WebMay 24, 2024 · The KLF4 gene is itself a CAD GWAS risk allele with the putative variant (rs944172) located ≈265 kb upstream of the KLF4 transcription start site. The nature of this variant is unclear; however, it overlaps a weak AP1 binding site with some evidence for … mercola find safe cookware

Frontiers Krüppel-Like Factors in Metabolic Homeostasis and ...

WebJan 1, 2008 · Herein we hypothesize that KLF4 is an important regulator in different phase of atherosclerosis and may be a novel target of prevention and cure of atherosclerosis. Further investigation is needed to approach the concrete signaling pathways about KLF4. WebNov 19, 2012 · Here, we show that endothelial KLF4 is an essential determinant of atherogenesis and thrombosis. Using in vivo EC-specific KLF4 overexpression and knockdown murine models, we found that KLF4 induced an antiadhesive, antithrombotic … WebFeb 8, 2024 · KLF4 promotes phenotypic modulation into macrophage-like and Sca1-expressing mesenchymal-like VSMCs, while MSCs differentiate into VSMCs in vitro when exposed to TGFβ and PDGF-BB. VSMCs might also derive from ECs following EndMT driven by TGFβ signalling. how old is gakpo

Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate

Kruppel-like factors - Wikipedia

WebMay 18, 2015 · On the basis of in vivo KLF4 chromatin immunoprecipitation–sequencing (ChIP-seq) analyses and studies of cholesterol-treated cultured SMCs, we identified >800 KLF4 target genes, including many... WebJun 4, 2015 · KLF4 is also a crucial factor for the generation of induced pluripotent stem cells 9. It has also recently been shown that loss of Klf4 in endothelial cells (ECs) or myeloid cells results in... how old is galantisWebJan 1, 2024 · These results indicate that formononetin may regulate KLF4 expression during atherosclerosis development. Given the role of KLF4 and SRA in atherogenesis, we postulate that formononetin may be antiatherogenic, in part, through regulation of KLF4-SRA … mercola fish oil

"WebMar 1, 2024 · Atherosclerosis is an important problem in modern medicine, the keys to understanding many aspects of which are still not available to clinicians. ... The large family of KLFs in humans includes 18 members, among which KLF2 and KLF4 are at the crossroads between endothelial cell mechanobiology and immunometabolism, which play … " - Klf4 atherosclerosis

Klf4 atherosclerosis

Frontiers Krüppel-Like Factors in Metabolic Homeostasis and ...

WebFeb 13, 2024 · KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Nat Med. 2015; 21:628–637. doi: 10.1038/nm.3866 Crossref Medline Google Scholar; 13. Cherepanova OA, Gomez D, Shankman LS, Swiatlowska P, Williams J, Sarmento OF, Alencar GF, Hess DL, Bevard MH, … WebOn the basis of in vivo KLF4 chromatin immunoprecipitation-sequencing (ChIP-seq) analyses and studies of cholesterol-treated cultured SMCs, we identified >800 KLF4 target genes, including many that regulate pro-inflammatory responses of SMCs.

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WebAtherosclerosis, the leading cause of death, is a vascular disease of... WebJun 29, 2024 · In macrophages, miR-34a regulated M1 and M2 macrophage polarization as well as cholesterol efflux via liver X receptor å (LXRå) and Kruppel-like factor 4 (KLF4). Consistent with these findings, macrophage-selective or global ablation of miR-34a markedly inhibited the development of atherosclerosis in Ldlr-/-mice or Apoe-/-mice. Finally ...

WebAtherosclerosis, the leading cause of death, is a vascular disease of... WebKLF4 plays an important role in several vascular diseases where it was shown to regulate vascular inflammation by controlling macrophage polarization and plaque formation in atherosclerosis. It up-regulates Apolipoprotein E, which is an anti-atherosclerotic factor. It is also involved in the regulation of angiogenesis.

WebDec 5, 2024 · Our study indicates that KLF4 mediates the link between glycolytic switch and VSMCs phenotypic transitions, suggesting that a previously unrecognized KLF4-eEF1A2/circCTDP1-PFKFB3 axis plays... WebOct 11, 2012 · In summary, our observations implicate myeloid KLF4 as a key regulator of experimental atherogenesis in mice. The fact that KLF4 has been shown to confer favorable anti-inflammatory effects in both the …

WebFeb 1, 2024 · Concordantly, cardiac-specific Klf4–/– mice develop heart dysfunction with aging or pressure overload associated with reduced ATP production, increased reactive oxygen species production, and mitochondrial dysfunction.

WebDec 13, 2024 · KLF4 is a zinc-finger-containing transcription factor that plays a crucial role in maintaining cell senescence in response to cellular stress. Studies have shown that KLF4 typically upregulates p21 to promote cell growth arrest ( Chew et al., 2011 ). how old is gakupoWebOn the basis of in vivo KLF4 chromatin immunoprecipitation-sequencing (ChIP-seq) analyses and studies of cholesterol-treated cultured SMCs, we identified >800 KLF4 target genes, including many that regulate pro-inflammatory responses of SMCs. mercola foundation trainingWebJan 1, 2024 · As a zinc finger domain-containing transcription factor, KLF4 involves in atherosclerosis development 27, 65. More importantly, it is reported that KLF4 is a critical regulator of macrophage polarization, and expression of KLF4 was robustly induced in M2 macrophages while markedly reduced in M1 macrophages 31. mercola food pyramidWebNov 26, 2024 · In this mechanism induced by oxidized low-density lipoprotein (oxLDL), the KLF4 factor suppresses the expression of VSMC genes (SM22α, ACTA2, MYH11) by binding to the G/C repressor element in the gene promoter and by inhibiting the binding of transcription factors to the CArG element mechanism, leading to phenotypic switching ( … how old is gajeel from fairy tailWebDec 1, 2014 · Blockade of mir-92a restores Klf2 and Klf4 expression, reduces endothelial inflammation and monocyte infiltration, thereby limiting atherosclerosis. 19 Disturbed flow and other proatherogenic factors also downregulate the endothelial expression of negative guidance cues, particularly Netrin-1 and Semaphorin3A, while upregulating EphrinB2, and … mercola grounding on earthWebMar 29, 2024 · CSC increased the expression of inflammatory markers and reduced the contractile ones in both cell types, with KLF4 modulating the SMC phenotypic switch. Next, we performed a mass spectrometry-based differential proteomic approach on human SMCs and could show 11 proteins were significantly affected by exposition to CSC (FC ≥ 2.7, p ≤ … how old is galbatorixWebJul 1, 2024 · KLF4 is an important transcription factor of VSMCs phenotypic transformations, macrophage polarization, lymphocyte differentiation, and cell proliferation as atherosclerosis progression 29, 30,... mercola free shipping